Targeted metabolomics-Wuhan Biobank Co., Ltd.

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Targeted metabolomics

Product Description

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Targeted metabolomics analysis is the targeted and specific detection and analysis of the specified metabolites in the list by using standard samples as controls.

The key points of targeted metabolomics analysis are high accuracy, high throughput and high reliability. Although this type of analysis is more routine than metabolic profiling, it can be used for very large numbers of samples.

Targeted metabolomics can be applied to.

(1) Validating new findings and hypotheses proposed by metabolomics experiments;

(2) Conducting hypothesis-based exploratory experiments and studying metabolic models for specific metabolites.

Basic Research Process

The process of targeted metabolomics research can be divided into: sample collection, standard curve creation, metabolite extraction and isolation, on-line assay, and data analysis.

Sample types

Serum - Plasma - Urine - Cerebrospinal fluid - Saliva - Feces - Microorganisms - Cells - Plants - Tissues - Others

Targeted metabonomics services and cycles are shown in the following table:

**靶向代谢组学服务和周期**
平台	仪器型号	代谢物	化合物数目	检测周期	检测价格
GC-MS/MS	Aglient 7890A-5975C或8890-7010B	短链脂肪酸	11种短链脂肪酸	约15个工作日	请询价
GC-MS/MS	Aglient 7890A-5975C或8890-7010B	游离脂肪酸	37种游离脂肪酸	约15个工作日	请询价
UHPLC-QqQ MS	SCIEX QTRAP 4500或Triple Quad 4500	维生素	12种水溶性	约20个工作日	请询价
		氨基酸	32种氨基酸
		神经递质	27种神经递质
		植物激素	10种植物激素
		胆汁酸	48种胆汁酸
		辅酶	18种辅酶
		抗生素	105种抗生素

**11种短链脂肪酸绝对定性定量分析**
序号	中文名称	英文名称	分子式	CAS号	相对分子质量
1	乙酸	acetic acid	C₂H₄O₂	64-19-7	60.05
2	丙酸	propionic acid	C₃H₆O2	79-09-4	74.08
3	异丁酸	isobutyric acid	C₄H₈O₂	79-31-2	88.11
4	丁酸	n-butyric acid	C₄H₈O₂	107-92-6	88.11
5	异戊酸	isovaleric acid	C₅H₁₀O₂	503-74-2	102.13
6	戊酸	n-valeric acid	C₅H₁₀O₂	109-52-4	102.13
7	4-甲基戊酸	4-methylvaleric acid	C₆H₁₂O₂	646-07-1	116.16
8	正己酸	hexanoic acid	C₆H₁₂O₂	142-62-1	116.15
9	2-甲基己酸	2-methylhexanoic acid	C₇H₁₄O₂	4536-23-6	130.18
10	正庚酸	n-heptylic acid	C₇H₁₄O₂	111-14-8	130.18
11	正辛酸	n-octanoic acid	C₈H₁₆O₂	124-07-2	144.21

**37种游离脂肪酸绝对定性定量分析**
编号	中文名称	英文名称	简写
1	丁酸	butyric acid	C4:0
2	己酸	caproic acid	C6:0
3	辛酸	caprylic acid	C8:0
4	癸酸	capric acid	C10:0
5	十一烷酸	undecanoic acid	C11:0
6	月桂酸	lauric acid	C12:0
7	十三烷酸	tridecanoic acid	C13:0
8	十四酸	myristic acid	C14:0
9	十四碳烯酸	myristoleic acid	C14:1n5
10	十五烷酸	pentadecanoic acid	C15:0
11	顺-10-十五碳烯酸	cis-10-pentadecenoic acid	C15:1n5
12	棕榈酸	palmitic acid	C16:0
13	棕榈油酸	palmitoleic acid	C16:1n7
14	十七烷酸	heptadecanoic acid	C17:0
15	顺-10-十七烯酸	cis-10-heptadecenoic acid	C17:1n7
16	硬脂酸	stearic acid	C18:0
17	反油酸	elaidic acid	C18:1n9t
18	油酸	oleic acid	C18:1n9c
19	反亚油酸	linolelaidic acid	C18:2n6t
20	亚油酸	linoleic acid	C18:2n6c
21	γ-亚麻酸	r-linolenic acid	C18:3n6
22	α-亚麻酸	α-linolenic acid	C18:3n3
23	花生酸	arachidic acid	C20:0
24	顺-11-二十碳烯酸	cis-11-eicosenoic acid	C20:1
25	顺-11,14-二十碳二烯酸	cis-11,14-eicosadienoic acid	C20:2
26	顺-8,11,14-二十碳三烯酸	cis-8,11,14-eicosatrienoic acid	C20:3n6
27	花生四烯酸	arachildonic acid	C20:4n6
28	二十一烷酸	heneicosanoic acid	C21:0
29	顺-11,14,17-二十碳三烯酸	cis-11,14,17-eicosatrienoic acid	C20:3n3
30	顺-5,8,11,14,17-二十碳三烯酸	cis-5,8,11,14,17-eicosatrienoic acid	C20:5n3
31	山萮酸	behenic acid	C22:0
32	芥酸	erucic acid	C22:1n9
33	顺-13,16-二十二碳二烯酸	cis-13,16-docosadienoic acid	C22:2
34	三十烷酸	tricosanoic acid	C23:0
35	顺-4,7,10,13,16,19-二十二碳六烯酸	cis-4,7,10,13,16,19-docosahexaenoic acid	C22:6n3
36	二十四碳酸	lignceric acid	C24:0
37	神经酸	nervonic acid	C24:1n9

**12种水溶性维生素绝对定性定量分析**
编号	物质名称	英文名称	分子量
1	VB1硫胺素	thiamine	264.35
2	VB2核黄素	Riboflavin	376.36
3	VB3烟酰胺	Nicotinamide	122.12
4	VB5泛酸	(R)-pantothenicacid	219.24
5	VB6吡哆胺	pyridoxamine	168.19
6	VB6吡哆醇	Pyridoxine	169.18
7	VB6吡哆醛	pyridoxal	167.16
8	VB7生物素	Biotin	244.31
9	VB9叶酸	folic acid	441.40
10	VB12钴胺素碎片	Vitamin B12	1355.37
11	对氨基苯甲酸	p-aminobenzoic acid	137.14
12	硫辛酸	thioctic acid	206.33

**32种氨基酸绝对定性定量分析**
编号	中文名称	英文名称	缩写
1	丙氨酸	alanine	ALA
2	肌氨酸	sarcosine	SAR
3	甘氨酸	glycine	GLY
4	α-氨基丁酸	α-aminobutyric acid	ABA
5	缬氨酸	valine	VAL
6	β-氨基异丁酸	β-aminobutyric acid	β-AIB
7	亮氨酸	leucine	LEU
8	别异亮氨酸	allo-isoleucine	aILE
9	异亮氨酸	isoleucine	ILE
10	苏氨酸	threonine	THR
11	丝氨酸	serine	SER
12	脯氨酸	proline	PRO
13	天冬酰胺	asparagine	ASN
14	硫代脯氨酸	thioproline	TPR
15	天冬氨酸	aspartic acid	ASP
16	蛋氨酸	methionine	MET
17	羟基脯氨酸	4-hydroxyproline	4-HYP
18	谷氨酸	glutamic acid	GLU
19	苯丙氨酸	phenylalanine	PHE
20	α-氨基己二酸	ɑ-aminoadipic acid	AAA
21	α-氨基庚二酸	ɑ-aminopimelic acid	APA
22	谷氨酰胺	glutamine	GLN
23	鸟氨酸	ornithine	ORN
24	甘氨酰-脯氨酸（二肽）	glycyl-proline	GPR
25	赖氨酸	lysine	LYS
26	组氨酸	histidine	HIS
27	羟基赖氨酸	hydroxylysine	HLY
28	酪氨酸	trrosinre	TYR
29	脯氨酸-羟基脯氨酸（二肽）	proline-hydroxyproline	PHP
30	色氨酸	tryptophan	TRP
31	胱硫醚	cystathionine	CTH
32	胱氨酸	cystine	C-C

**27种神经递质绝对定性定量分析**
编号	中文名字	英文名字	缩写	分类	CAS号
1	色胺	Tryptamine	-	单胺类吲哚类	61-54-1
2	5-羟色胺	Serotonin hydrochloride	5-HT	单胺类吲哚类	153-98-0
3	5-羟吲哚乙酸	5-hydroxyindoleacetic acid	5HIAA	单胺类吲哚类	54-16-0
4	犬尿喹啉酸	Kynurenic acid	KYNA	单胺类吲哚类	492-27-3
5	褪黑激素	Melatonin	-	单胺吲哚类	73-31-4
6	5-羟基色氨酸	5-Hydroxy-Tryptophan	5-HTP	单胺吲哚类	4350-09-8
7	肾上腺素	Epinephrine	EP	单胺类儿茶酚胺类	329-63-5
8	去甲肾上腺素	noradrenaline bitartrate	NE	单胺类儿茶酚胺类	108341-18-0
9	多巴胺	Dopamine	DA	单胺类儿茶酚胺类	62-31-7
10	高香草酸	homovanillic acid	NMN	单胺类儿茶酚胺类	306-08-1
11	香草扁桃酸	4-hydroxy-S-methoxymandelic acid	VM-A	单胺类儿茶酚胺类	55-10-7
12	去甲变肾上腺素	rac Normetanephrine	-	单胺类儿茶酚胺类	1011-74-1
13	3-甲氧酪胺	3-Methoxy-p-tyramine	-	单胺类儿茶酚胺类	1477-68-5
14	酪胺	Tyramine	-	单胺类儿茶酚胺类	51-67-2
15	二羟苯乙酸	3,4-Dihydroxyphenylacetic acid	DOPAC	单胺类儿茶酚胺类	102-32-9
16	胆碱	Choline Chloride	-	单胺类胆碱类	67-48-1
17	乙酰胆碱	Acetylcholine	Ach	单胺类胆碱类	60-31-1
18	组胺	Histamine	-	氨基酸类	51-45-6
19	犬尿氨酸	Kynurenine	-	氨基酸类	2922-83-0
20	谷氨酰胺	Glutamine	GLN	氨基酸类	56-85-9
21	谷氨酸	Glutamic Acid	GLU	氨基酸类	56-86-0
22	4-氨基丁酸	4-Aminobutyric Acid	GABA	氨基酸类	56-12-2
23	酪氨酸	Tyrosine	TYR	氨基酸类	60-18-4
24	精氨酸	Arginine	Arg	氨基酸类	74-79-3
25	组氨酸	Histidine	HIS	氨基酸类	71-00-1
26	苯基丙氨酸	Phenylalanine	PHE	氨基酸类	63-91-2
27	色氨酸	Tryptophan	TRP	氨基酸类	73-22-3

**10种植物激素绝对定性定量分析**
编号	中文名	英文名	简称
1	反-玉米素	Trans-Zeatin	t-ZT
2	赤霉素	Gibberellin A3	GA3
3	吲哚乙酸	3-Indoleacetic acid	IAA
4	水杨酸	Salicylic acid	SA
5	茉莉酸	Jasmonic acid	JA
6	脱落酸	Abscisic acid	ABA
7	吲哚丁酸	3-Indolebutyric acid	IBA
8	6-苄氨基嘌呤	6-Benzylaminopurine	6-BA
9	茉莉酸甲酯	Methyl jasmonate	JA-ME
10	激动素	6-Furfurylaminopurine	6-KT

**48种胆汁酸绝对定性定量分析**
编号	简称	常用名	编号	简称	常用名
1	DLCA	Dehydrolithocholic acid	25	3β-CA	3β-Cholic Acid
2	LCA	Lithocholic acid	26	α-MCA	α-Muricholic acid
3	ILCA	Isolithocholic acid	27	12-DHCA	12-Dehydrocholic acid
4	NDCA	23-Nordeoxycholic acid	28	λ-MCA （HCA)	λ-Muricholic acid
5	6-KLCA	6-Ketolithocholic acid	29	CA	Cholic acid
6	7-KLCA	7-Ketolithocholic acid	30	AlCA	Allocholic acid
7	12-KLCA	12-Ketolithocholic acid	31	GLCA	Glycolithocholic acid
8	ApCA	Apocholic acid	32	GCDCA	Glycochenodeoxycholic acid
9	MoCA	Murocholic acid	33	TLCA	Taurolithocholic acid
10	TCDCA-d5	Taurochenodeoxycholic-d5 acid	34	GHDCA	Glycohyodeoxycholic acid
11	β-HDCA	β-Hyodeoxycholic Acid	35	GDHCA	Glycodehydrocholic acid
12	UDCA	Ursodeoxycholic acid	36	λ-GMCA (GHCA)	Glyco-λ-muricholic acid
13	CDCA	Chenodeoxycholic acid	37	TDCA	Taurodeoxycholic acid
14	DHCA	Dehydrocholic acid	38	GUDCA	Glycoursodeoxycholic acid
15	HDCA	Hyodeoxycholic acid	39	TUDCA	Tauroursodeoxycholic acid
16	IDCA	Isodeoxycholic acid	40	THDCA	Taurohyodeoxycholic acid
17	NCA	23-Norcholic acid	41	TCA	Taurocholic acid
18	DCA	Deoxycholic acid	42	GDCA	Glycodeoxycholic acid
19	DiLCA	Dioxolithocholic acid	43	TDHCA	Taurodehydrocholic acid
20	6,7-DKLCA	6,7-Diketolithocholic acid	44	α-TMCA	Tauro-α-muricholic acid
21	7-KDCA	7-Ketodeoxycholic acid	45	β-TMCA	Tauro-β-muricholic acid
22	β-MCA	β-Muricholic acid	46	λ-TMCA	Tauro-λ-muricholic acid
23	3-DHCA	3-Dehydrocholic acid	47	ω-TMCA	Tauro-ω-muricholic acid
24	UCA	Ursocholic acid	48	GCA	Glycocholic acid

**18种辅酶绝对定性定量分析**
序号	常用名	中文名字
1	NAD+	氧化烟酰胺腺嘌呤二核苷酸
2	NADP+	氧化烟酰胺腺嘌呤二核苷酸磷酸
3	NADH	还原型烟酰胺腺嘌呤二核苷酸
4	NADPH	还原型酰胺腺嘌呤二核苷酸磷酸
5	ATP	三磷酸腺苷
6	ADP	二磷酸腺苷
7	AMP	一磷酸腺苷
8	Creatinephosphate	磷酸肌酸
9	Creatine	肌酸
10	Creatinine	肌苷
11	2'-deoxyuridine	脱氧尿苷
12	Cytosine	胞嘧啶
13	Adenosine	腺苷
14	Thymine	胸腺嘧啶
15	Cytidine	胞啶
16	Uridine	尿苷
17	Guanosine	鸟苷
18	UMP	尿苷酸

**105种抗生素绝对定性定量分析**
物质类别	物质列表
Sulfonamides （磺胺类：30种）	sulfapyridine, sulfadoxine, sulfathiazole, sulfamethizole, sulfamethazine, sulfadiazine, sulfaquinoxaline, sulfachloro pyridazine, sulfisomidine, sulfadimethoxine, sulfaguanidine, sulfanilamide, sulfacetamide, sulfamerazine, sulfamoxole, succinylsulfathiazole, sulfamethoxazole, sulfamethoxypyridazine, sulfamonomethoxine, sulfisoxazole, sulfanitran, sulfaclozine , sulfameter , trimethoprim, sulfasalazine, N-acetylsulfapyridine, N-acetylsulfadiazine, N-acetylsulfamethazine, N-acetylsulfamethoxazole, N-acetylsulfamerazine
Quinolones （喹诺酮类：20种）	enrofloxacin, ciprofloxacin, danofloxacin, difloxacin, enoxacin, lomefloxacin, norfloxacin, ofloxacin, pefloxacin, sarafloxacin, sparfloxacin, cinoxacin, moxifloxacin, flumequine, pipemidic acid, nalidixic acid, fleroxacin, oxolinic acid, piromidic acid, levofloxacin
Tetracyclines （四环素类：14种）	oxytetracycline, tetracycline, chlortetracycline, minocycline, methacycline, doxycycline, 4-epianhydrotetracycline, Isochlortetracycline, 4-epitetracycline, anhydrotetracycline, 4-epianhydrochlortetracycline, 4-epioxytetracycline, α-apo-oxytetracycline, β-apo-oxytetracycline
Macrolides （大环内酯类：16种）	erythromycin, clarithromycin, clindamycin, roxithromycin, tilmicosin, lincomycin, ormetoprim, oleandomycin, azithromycin, virginiamycin M1, virginiamycin S1, kitasamycin, spiramycin, tylosin, midecamycin, midecamycin
β-lactams （β-内酰胺类：14种）	Cefalexin, cefradine, cefotaxime, ampicillin, amoxicillin, dicloxacillin, cefazolin, cloxacillin, cefaclor, penicillin V, cefapirin, piperacillin, ceftiofur, penicillin G
Chloramphenicols （氯霉素类：3种）	chloramphenicol, thiamphenicol, florfenicol
Polypeptides and other antibiotics （多肽和其他抗生素：8种）	bacitracin A, colistin A, colistin B, furazolidone, monensin, salinomycin, narasin, tiamulin

Project advantages

a. Standardized technical platform: with standardized experimental operation specifications and advanced technical platform, short experimental period and reliable quality.

b. Advanced detection equipment: Aglient 7890A/5975C single quadrupole gas-mass spectrometer, Aglient 8890-7010B triple quadrupole gas-mass spectrometer, SCIEX TripleTOF 5600 plus high-resolution mass spectrometer, SCIEX QTRAP 4500 and SCIEX Triple Quad 4500 triple quadrupole mass spectrometry systems, and Agilent 600 M metabolomics analysis platforms such as ultra-low temperature nuclear magnetic resonance spectrometer.

c. Professional database: several commercial databases are available, while over one hundred standard sample databases have been established to make the characterization more accurate.

d. Multiple quality control guarantees: the analysis process adopts strict method validation steps to ensure reliable experiments.

e. Provide customized services: With professional bioinformatics team and large computer cluster, we can provide partners with personalized bioinformatics analysis services.

f. Complete after-sales service: perfect after-sales service, from report interpretation to article publication, can provide efficient and high-quality service throughout the whole process.

g. Diversified development types: Several major categories of common metabolites have been developed for targeted metabolomics analysis, such as metabolic pathways, targeted metabolites, plant metabolites, organic compounds, inorganic compounds, oxidative stress compounds, etc.