Single Cell ATAC-Wuhan Biobank Co., Ltd.

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Single Cell Sequencing Service
- Single Cell Sequencing
- Spatial transcriptome sequencing
  - Spatial Gene Expression for Fresh Frozen
  - Spatial Gene Expression for FFPE
High throughput sequencing services
Cell-based immune-related assays
Proteomics Testing Services
- Proteomics services by LC/MS
- Olink Proteomics Services
  - Olink Precision Proteomics Analysis Service
Small molecule metabolite detection services
- Metabolomics Services
  - Targeted metabolomics
  - Non-targeted metabolomics
- Nucleic acid mass spectrometry detection service

Single Cell ATAC

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Single-cell ATAC-seq is to study chromatin accessibility at the single-cell level and is mainly used for the detection of transcriptional regulatory sequences, which can be combined with single-cell RNA-seq to analyse all actively transcribed regulatory sequences in the genome. This technique has been used in many research areas such as tumor heterogeneity studies, gene regulatory network analysis, cell lineage tracing, biomarker discovery, etc.

ATAC-Seq (Assay for Transposase Accessible Chromatin with high-throughput sequencing) uses Tn5 transposase to cleave nuclear chromatin regions which is open at a specific space-time and then adds primers for high-throughput sequencing to obtain the regulatory sequences of all active transcripts in the genome at that specific space-time condition.

ATAC-Seq schematic diagram

The single cell ATAC-Seq technology relies on the microfluidic technology of the 10x Genomics platform, combining characteristics of different cells of sequence tags distinguished population with ATAC-Seq technology to build chromatin accessibility profiles for thousands of single cells. Sample types: cell lines, primary cells, fresh and frozen tissues, etc.