Multi-omics Scientific Research Platform

Multi-omics Scientific Research Platform

　　 Platform Introduction

The construction of the multi-omics scientific research platform of Wuhan Biobank is based on the Public Technical Service Platform of the Wuhan Institute of Biotechnology. It focuses on building four major platforms: high-throughput sequencing, single-cell sequencing, mass spectrometry and nuclear magnetic resonance, and cell structure and function. The platform aligns with cutting-edge international omics research directions and the latest detection technologies, concentrating on innovative research in fields such as cardiovascular diseases, tumors, neurological disorders, metabolic diseases, and neonatal genetic disorders. It aims to develop multi-omics detection methods and analytical approaches, and through the integrated analysis of high-throughput omics data from multiple levels and sources, systematically study disease mechanisms, identify optimal disease targets, and provide new theoretical foundations for new drug development, early disease diagnosis, personalized treatment, and guidance on medication use. In response to project needs, we offer comprehensive project solutions and specialized bioinformatics analysis services to help researchers correctly interpret the data.

Single-cell sequencing platform

NGS platform

Mass Spectrometry Platform (Proteomics, Metabolomics)

Cell platform

Development History

Platform establishment

2011 The Bio-Office is establishing a public technical service platform for the research institute.

2012 The instrument and equipment have been installed in place.
Officially operational

2013 Officially in operation to the public
Official certification

2015 Obtain CNAS accreditation

2016 Obtain CMA certification
Rapid development

2017 The cumulative number of samples tested has exceeded 20,000.

2018 We have served over 600 clients cumulatively and signed more than 5,000 agreements and contracts.
A New Journey

2019 The platform has been fully transferred to the Wuhan National Human Genetic Resources Bank.

2021 Integrate six major areas—high-throughput sequencing, single-cell sequencing, mass spectrometry and nuclear magnetic resonance, as well as cellular structure and function—into four platforms.

　　 Joint application of multi-omics studies

　　A multi-omics technology integration platform performs statistical analyses—including data normalization, comparative analysis, and correlation analysis—on large-scale datasets derived from various biomolecular levels such as the genome, transcriptome, proteome, and metabolome, thereby establishing relationships among molecular entities at different levels. At the same time, this platform integrates biological functional analyses—including GO functional annotation, metabolic pathway enrichment, and molecular interaction studies—to systematically and comprehensively elucidate the functions and regulatory mechanisms of biomolecules. This provides big data support for new drug development, early disease diagnosis, personalized treatment, and guidance on medication use.

　　The key multi-omics research areas being actively pursued include:

　　(1) Research on genome, exome, and transcriptome sequencing in clinical cancer genomics. By performing genome, exome, and transcriptome sequencing, we study gene structures to identify structural variations, somatic mutations, and pathogenic mutations associated with tumors.

　　(2) Multi-omics study of microbial secondary metabolites. This research leverages genomics, transcriptomics, proteomics, and metabolomics data from gut microbiota to explore the relationships between disease onset, progression, and recovery and the gut microbiome, as well as to investigate drug metabolism pathways.