Multi-omics science research platform
Based on the public technical service platform of Wuhan Institute of Biotechnology, the multi-omics scientific research platform of Wuhan Biobanks builds four research platforms of high-throughput sequencing, single cell sequencing, biomass spectroscopy and nuclear magnetic resonance technology, and cell structure and function. The platform follows the international cutting-edge omics study directions and the latest test technology, and focuses on the innovative research in cardiovascular diseases, tumors, neurological disease, metabolic diseases, neonatal genetic diseases and other fields in order to develop more multi-omics detection methods and analysis methods. Through the integrated analysis of high-throughput omics data from multiple sources, the platform systematically studies the pathogenesis of diseases and finds the best disease targets, providing new theoretical basis for the development of new drugs, early diagnosis of diseases, individualized treatment and drug guidance. According to the project requirements, the platform provides complete solutions and professional bioinformatics analysis to assist researchers to correctly interpret the information.
发展历程
Combined application of multi-group research
Multiomics technology integration platform, which carries out normalization, comparative analysis, correlation analysis and other statistical analysis on batch data from different biomolecular levels such as genome, transcriptome, proteome and metabolome, and establishes data relationships between different levels of molecules; At the same time, combined with GO function analysis, metabolic pathway enrichment, molecular interaction and other biological function analysis, systematically and comprehensively analyze the biological molecular function and regulatory mechanism, providing big data support for new drug research and development, early diagnosis of disease, individualized treatment and drug guidance.
The key research directions of multi-omics include:
(1) The study of genome, exome and transcriptome sequencing in clinical cancer genomics. Through genome, exon and transcriptome sequencing, the gene structure was studied to find structural mutations, somatic mutations and pathogenic mutations related to tumor.
(2) Multigroup study of microbial secondary metabolites. The research uses the genomics, transcriptomics, proteomics and metabolomics detection data of intestinal microorganisms to find the relationship between the occurrence, development, cure and intestinal microorganisms, and study the drug metabolism pathway.
