Column name (in Chinese and English) and TCLSIH cohort study: Tianjin chronic low-grade systemic inflammation and health cohort study; Registration No.: UMIN000027174.
Project leader (lead unit) Niu Kaijun (Tianjin Medical University)
Project introduction This research was started in 2007 to explore the inherent law of immune system/chronic inflammation in the process of aging and its related diseases, identify key risk factors, and provide scientific basis for effective prevention and control of the spread of chronic diseases. Baseline data of more than 300000 adults have been collected (including comprehensive medical information, occupation, medical history, smoking, drinking, exercise and other basic questionnaires) and long-term follow-up has been conducted once every 1-2 years. In addition, since 2013, the cohort has developed a comprehensive lifestyle and environment questionnaire (including the reliability and validity verification food frequency questionnaire FFQ, depression symptoms, standardized physical activity scale, sleep, Internet addiction, loneliness, education, income, etc.) and has evaluated the data collection work of more than 80000 people. Among them, there are more than 15000 elderly myopenia patients (CGA) and more than 2000 super-aged (over 85 years old) longevity patients.
Main purpose: research and development of prediction, prevention and control strategies for aging and related diseases (including chronic diseases); Build immune epidemiology.
Study Design An open prospective cohort study of adult population.
Inclusion criteria: adults over 18 years old.
Exclusion criteria: disabled, semi-disabled, refused or unable to cooperate with the investigation.
The characteristics of the population come from the physical examination centers at different levels in Tianjin and the adult population over 18 years old in the community. The population composition of age, sex and occupation is matched.
The number of people completed/the target number is more than 300000.
Start and end years and follow-up interval 2007 -; Follow up every 1-3 years.
The contents of the questionnaire include age, sex, nationality, marital and child status, smoking, drinking, occupation, education background, family income, physical activity scale (IPAQ), food frequency method questionnaire (FFQ, verified by reliability and validity), sleep status, social activity, menstrual status, cognitive function (MMSE), well-being index, depression scale (SDS), loneliness scale, mobile phone and other screen use time/internet addiction and other lifestyle, disease history Family history and environmental pollution questionnaire, etc.
Medical examination and measurement indicators: blood pressure, heart rate, height, weight, waist circumference, hip circumference, grip strength, 4-meter walking speed, body composition detection, face recognition, genome (GWAS chip detects more than 6000 people), proteome, metabolome, intestinal flora, lung function, chest radiograph, electrocardiogram, thyroid ultrasound, abdominal ultrasound, breast and gynecology ultrasound, carotid ultrasound, bone mineral density; Helicobacter pylori examination; Fasting blood glucose, glycosylated hemoglobin, 2h postprandial blood glucose, triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein, blood uric acid, ferritin, albumin, various immunoglobulins (IgG, IgE, IgM, IgA), complement C3, C4, and high-sensitivity C-reactive protein, alanine aminotransferase, glutamic-oxalate aminotransferase, etc; Various tumor markers; A work (FT3, FT4 and TSH); Fibrinogen content, blood routine, urine routine, stool routine; Various cancer markers (alpha-fetoprotein, ferritin, carcinoembryonic antigen, sugar chain antigen 19-9, sugar chain antigen 242, anti-squamous cell carcinoma antigen, prostate specific antigen (male), free prostate antigen, human epididymal epithelial secretory protein 4, sugar chain antigen 15-3, etc.).
Outcome indicators: diabetes, hypertension, hyperlipidemia, fatty liver, common carotid atherosclerosis, atrial fibrillation, benign breast disease, disability and semi disability, cardiovascular and cerebrovascular diseases, cancer, myopenia, healthy life and all-cause death.
Blood samples from biological sample bank, about 60000 people; About 5000 urine samples; Fecal samples are about 2000 people.
The main results have been followed up for up to 13 years. Published more than 110 SCI papers.
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