Multiomics scientific research platform

Description: Multiomics scientific research platform   Platform introduction The construction of the multi-omics scientific research platform of Wuhan Biological Sample Bank Co., Ltd. is based on the public technology service platform of Wuhan Institute of Biotechnology, focusing on building four major platforms: high-throughput sequencing, single-cell sequencing, biological mass spectrometry and nuclear magnetic resonance, cell structure and function, benchmarking the international frontier research direction and the latest detection technology of genomics, focusing on innovative research in cardiovascular disease, tumor, neuropathy, metabolic disease, neonatal genetic disease and other fields, Develop multi-omics detection methods and analysis methods, systematically study the pathogenesis of disease, determine the best disease target, and provide new theoretical basis for new drug research and development, early diagnosis of disease, individualized treatment and medication guidance through the integration and analysis of high-throughput omics data from various levels and sources. According to the needs of the project, provide complete project solutions and professional student information analysis to assist researchers in correct information interpretation. Single cell sequencing platform NGS platform Mass spectrometry platform (proteome, metabolome) Cell platform   development history Platform preparation   In 2011, the Office of Biology prepared to build the public technology service platform of the Institute In 2012, instruments and equipment were installed in place Formal operation   Officially put into operation in 2013 Authoritative certification   CNAS recognition in 2015 Obtained CMA certification in 2016 Rapid development   In 2017, the cumulative number of samples tested exceeded 20000 In 2018, it served more than 600 customers and signed more than 5000 agreements and contracts A new journey   In 2019, the platform will be transferred to Wuhan National Human Genetic Resources Database In 2021, four platforms including high-throughput sequencing, single-cell sequencing, biological mass spectrometry and nuclear magnetic resonance, and cell structure and function will be integrated in six directions Combined application of multi-group research Multiomics technology integration platform, which carries out normalization, comparative analysis, correlation analysis and other statistical analysis on batch data from different biomolecular levels such as genome, transcriptome, proteome and metabolome, and establishes data relationships between different levels of molecules; At the same time, combined with GO function analysis, metabolic pathway enrichment, molecular interaction and other biological function analysis, systematically and comprehensively analyze the biological molecular function and regulatory mechanism, providing big data support for new drug research and development, early diagnosis of disease, individualized treatment and drug guidance. The key research directions of multi-omics include: (1) The study of genome, exome and transcriptome sequencing in clinical cancer genomics. Through genome, exon and transcriptome sequencing, the gene structure was studied to find structural mutations, somatic mutations and pathogenic mutations related to tumor. (2) Multigroup study of microbial secondary metabolites. The research uses the genomics, transcriptomics, proteomics and metabolomics detection data of intestinal microorganisms to find the relationship between the occurrence, development, cure and intestinal microorganisms, and study the drug metabolism pathway.